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rmGlu1 V757L mutation results in significant loss of VU0410425 activity while hmGlu1 L757V mutation gains activity similar to that seen in rat WT. The effects of multiple fixed concentrations of VU0410425 on the glutamate CRCs of (a) rmGlu1 WT, (b) rmGlu1 V757L, (c) hmGlu1 WT, and (d) hmGlu1 L757V in a calcium mobilization assay using cells expressing mGlu1 are shown.
