Table 4. Sensitivity, Specificity, Positive and Negative Predictive Values of the ROMA Index, HE4, CA125 in Two Subgroups of Pre-menopause and Post-menopause Patients a,b.
| Under Menopause Age (n = 68) | Above Menopause Age (n = 31) | |||||
|---|---|---|---|---|---|---|
| CA125 (≥ 35) | HE4 (≥ 75) | ROMA (≥ 11.5) | CA125 (≥ 25) | HE4 (≥ 100) | ROMA (≥ 25.5) | |
| True Positive | 16 | 12 | 16 | 19 | 16 | 18 |
| False Positive | 13 | 2 | 7 | 0 | 0 | 0 |
| False Negative | 5 | 9 | 5 | 3 | 6 | 4 |
| True Negative | 34 | 45 | 40 | 9 | 9 | 9 |
| Sensitivity (95% CI) | 76.2 (55 - 89) | 57.1 (36 - 75) | 76.2 (55 - 89) | 86.4 (66 - 95) | 72.7 (51 - 86) | 81.8 (61 - 92) |
| Specificity (95% CI) | 72.3 (58 - 83) | 95.7 (86, 99) | 85.1 (72 - 93) | 100 (70 - 100) | 100 (70 - 100) | 100 (70 - 100) |
| Positive Predictive Value (95% CI) | 55.2 (38 - 72) | 85.7 (60.- 96) | 69.6 (49 - 84) | 100 (83 - 100) | 100 (80 - 100) | 100 (82 - 100) |
| Negative Predictive Value (95% CI) | 87.2 (73 - 94) | 83.3 (7 - 901) | 88.9 (76 - 96) | 75 (46 - 91) | 60 (35 - 80) | 69.2 (42 - 87) |
| Diagnostic Accuracy (95% CI) | 73.5 (62 - 83) | 83.8 (73 - 91) | 82.4 (71 - 90) | 90.3 (75 - 96) | 80.7 (63 - 90) | 87.1 (71 - 94) |
| Likelihood ratio of a Positive Test (95% CI) | 2.8 (2.2 - 3.3) | 13.4 (4.540.1) | 5.1 (3.7 -7.0) | - | - | - |
| Likelihood ratio of a Negative Test (95% CI) | 0.33 (0.21 - 0.50) | 0.45 (0.36 - 0.56) | 0.28 (0.18 - 0.42) | 0.14 (0.07095 - 0.2621) | 0.27 (0.1967 - 0.3781) | 0.18 (0.1114 - 0.2968) |
| Diagnostic Odds (95% CI) | 8.4 (2.5 - 27.5) | 30 (5.7 - 157.7) | 18.3 (5.0- 66.1) | - | - | - |
| Cohen's kappa (Unweighted) (95% CI) | 0.4 (0.2 - 0.7) | 0.6 (0.35 0.8) | 0.6 (0.36 0.8) | 0.8 (0.4 - 1.13) | 0.6 (0.2 - 0.9) | 0.7 (0.3 - 1.0) |
a Abbreviations: CI, confidence interval; ROMA, risk of ovarian malignancy algorithm.
b Data are presented as Median (Range).