TABLE I.
Baseline Characteristics of 114 Adults with Sickle Cell Disease and Comparison of Those with and without a Report of a Doctor-Diagnosis of Asthma
| SCD cohort n = 114 |
SCD cohort by asthma diagnosis
|
|||
|---|---|---|---|---|
| Asthma n = 34 |
No asthma n = 80 |
P value | ||
| Demographics | ||||
| Age, median (IQR) | 31.8 (17) | 27.1 (12) | 34.9 (16) | <0.01 |
| Gender, % male | 45 | 47 | 44 | 0.75 |
| SCD characteristics | ||||
| Phenotype, % (HbSS/HbSB∘) | 69 | 77 | 66 | 0.28 |
| Hemogloblin (g/dL), mean (SD) | 8.9 (1.8) | 8.6 (1.5) | 9.1 (1.9) | 0.18 |
| WBC (cells/μL), mean (SD) | 10.8 (3.1) | 11.6 (3.7) | 10.5 (2.8) | 0.11 |
| LDH, median (IQR) | 327.5 (218.5) | 331.5 (174) | 325.5 (241) | 0.65 |
| Hydroxyurea, % | 31 | 41 | 26 | 0.11 |
| Allergic characteristics | ||||
| Total Serum IgE, median (IQR) | 40.6 (86) | 64.3 (262) | 33.2 (71) | 0.04 |
| Eosinophil, % WBC, median (IQR) | 2.5 (3.3) | 2.8 (4.5) | 2.2 (3.1) | 0.43 |
| Family history of asthma, % | 24 | 44 | 16 | <0.01 |
| History of eczema, % | 8 | 18 | 4 | 0.01 |
| Asthma symptoms | ||||
| ≥2 episodes of wheezing with SOB, % | 30 | 53 | 20 | <0.01 |
| Wheezes in presence of cold, % | 61 | 85 | 51 | <0.01 |
| Wheezes in absence of cold, % | 30 | 59 | 18 | <0.01 |
| Wheezes with exercise, % | 39 | 59 | 30 | <0.01 |
| Cough in presence of cold, % | 86 | 91 | 84 | 0.39 |
| Cough in absence of cold, % | 42 | 56 | 36 | 0.052 |
IQR, inter-quartile range; LDH, lactate dehydrogenase; SCD, sickle cell disease; SD, standard deviation; SOB, shortness of breath; WBC, white blood cell.