TABLE III.
Association of Recurrent, Severe Wheezing and Report of Doctor-Diagnosis of Asthma with Rates of Pain and Acute Chest Syndrome in Adults with Sickle Cell Disease
| Variable n = 114 |
Model 1: Effect of doctor-diagnosed asthma on the rates of pain and ACS events
|
Model 2: Effect of recurrent, severe wheezing on the rates of pain and ACS events
|
||
|---|---|---|---|---|
| RR (95% CI) | P value | RR (95% CI) | P value | |
| Paina | ||||
| Recurrent, severe wheezing | 2.0 (1.2–3.4) | 0.005 | ||
| Doctor-diagnosed asthma | 0.99 (0.6–1.7) | 0.46 | ||
| ACSb | ||||
| Recurrent, severe wheezing | 2.1 (1.1–4.0) | 0.03 | ||
| Doctor-diagnosed asthma | 1.3 (0.7–2.6) | 0.97 | ||
ACS, acute chest syndrome; SCD, sickle cell disease.
a
Pain model was adjusted for SCD phenotype, age, gender, hemoglobin, tobacco smoking, hydroxyurea use.
b
ACS model was adjusted for SCD phenotype, age, hemoglobin, white blood cell count, tobacco smoking, hydroxyurea use.