Table 4. Summary table for the clustering of CDR-L2.
| Cluster | Population | Unique sequences |
Medoid PDB entry |
Medoid Ramachandran conformation |
Level-3 clusters |
Level-2 clusters |
Cluster diameter (Å) (furthest members) |
Best resolution in cluster (Å) (PDB) |
Species in cluster | Isotype |
|---|---|---|---|---|---|---|---|---|---|---|
| CDR-L2 7-residues, total population: 2161, total unique sequences: 278, clusters: 3, outliers/singletons: 2, Av.Silhouette: 0, 61 | ||||||||||
| L2-7-I | 2109 | 272 (98%) | 1dn0_C | LLDPPPP | 121 | 45 | 1.56 (3KYM_O-1nj9_A) | 1.2 (3D9A_L) | HUMAN, MOUSE, RABBIT, RAT, SEAL, HAMSTER, CHIMPANZEE, RAT, SYNTHETIC HUMANIZED ANTIBODY, CHIMERA OF MOUSE/HUMAN |
κ, λ |
| L2-7-II | 39 | 8 (3%) | 3RIA_L | GADBBPP | 12 | 5 | 1.04 (3RHW_K-3FKU_X) | 1.66 (3QHF_L) | HUMAN, MOUSE | κ, λ |
| L2-7-III | 11 | 2 (1%) | 2a6k_L | LLGGPPD | 8 | 3 | 0.75 (2ZJS_L-2V7H_L) | 2.5 (2a6i_A) | MOUSE | κ |
| CDR-L2 11-residues, total population: 13, total unique sequences: 3, clusters: 2, outliers/singletons: 0, Av.Silhouette: 0, 90 | ||||||||||
| L2-11-I | 10 | 2 (67%) | 2OTU_A | BPAALPBBPPP | 1 | 1 | 0.39 (2GSG_C-2OTU_C) | 1.68 (2OTU_A) | MOUSE | λ |
| L2-11-II | 3 | 1 (33%) | 2H32_A | BDBAABBBPPA | 3 | 2 | 0.2 (2H3N_C-2H3N_A) | 2.3 (2H3N_A) | HUMAN | λ |
| Total (level-1 clusters only) | 2172 | 145 | 56 | |||||||