Table 1. DCP terms and definitions.

A list of terms that were used for the formulation of the DCP method and their definitions.

Interaction Frame (IF)	A list of Fv positions that are found in the neighbourhood of the examined CDR, its residues included
IF sequence	A sequence of residues derived from an antibody’s Fv that correspond to the positions included in the IF
Query IF sequence set	A group of non-redundant IF sequences from all members of the cluster that is being profiled
Target IF sequence set	A group of non-redundant IF sequences from the members of all clusters in the examined length, excluding the cluster that is being profiled
IF fragment	A singlet or a non-necessarily consecutive combination of IF positions (couplet/triplet/quadruplet/etc.)
IF fragment sequence	The corresponding sequence of residues in an IF fragment
Query/Target fragment sequence	IF fragment sequences from the Query/Target IF sequence sets form Query/Target fragment sequences, respectively
Signature signal	An IF fragment that presents disjoint IF fragment sequences between Query and Target sets
DCP signature	The complete set of signature signals that are consequently used for the prediction of a given cluster