Table 6. Individual accuracy percentages per experiment in CDR-H1, -H2 and -H3, excluding non-predictable (novel) conformations.
Also see notes in Table 5.
| CDR-H1 predictions | |||||||
| Phase-1 Initial DCP signatures | Phase-2 Updated DCP signatures | Phase-1 Initial canonical templates | Phase-2 Updated canonical templates | ||||
| Training: clustering set Evaluation: validation set |
Training:
clustering set Evaluation: test set |
Training: clustering + validation sets Evaluation: validation set |
Training: clustering + validation sets Evaluation: test set |
Template Updating: clustering set Evaluation: validation set |
Template Updating:
clustering set Evaluation: test set |
Training: clustering + validation sets Evaluation: validation set |
Template Updating: clustering + validation sets Evaluation: test set |
| 96% (92/96) | 95% (91/96) | 100% (96/96) | 96% (92/96) | 79% (76/96) | 83% (80/96) | 83% (80/96) | 85% (82/96) |
| Cumulative evaluation on validation + test sets | Cumulative evaluation on validation + test sets |
Cumulative evaluation on validation + test sets |
Cumulative evaluation on validation + test sets |
||||
| 95% (183/192) | 98% (188/192) | 81% (156/192) | 84% (162/192) | ||||
| CDR-H2 predictions | |||||||
| Phase-1 Initial DCP signatures | Phase-2 Updated DCP signatures | Phase-1 Initial canonical templates | Phase-2 Updated canonical templates | ||||
| Training: clustering set Evaluation: validation set |
Training:
clustering set Evaluation: test set |
Training: clustering + validation sets Evaluation: validation set |
Training: clustering + validation sets Evaluation: test set |
Template Updating: clustering set Evaluation: validation set |
Template Updating:
clustering set Evaluation: test set |
Training: clustering + validation sets Evaluation: validation set |
Template Updating: clustering + validation sets Evaluation: test set |
| 93% (98/105) | 87% (94/108) | 100% (105/105) | 81% (87/108) | 58% (61/105) | 57% (62/108) | 64% (67/105) | 56% (61/108) |
| Cumulative evaluation on validation + test sets | Cumulative evaluation on validation + test sets |
Cumulative evaluation on validation + test sets |
Cumulative evaluation on validation + test sets |
||||
| 91% (193/213) | 90% (192/213) | 58% (123/213) | 60% (128/213) | ||||
| CDR-H3-base predictions | |||||||
| Phase-1 Initial DCP signatures | Phase-2 Updated DCP signatures | 1999 sequence rules | 2007 sequence rules | ||||
| Training: clustering set Evaluation: validation set |
Training:
clustering set Evaluation: test set |
Training: clustering + validation sets Evaluation: validation set |
Training: clustering + validation sets Evaluation: test set |
Evaluation: validation set |
Evaluation:
test set |
Evaluation: validation set |
Evaluation:
test set |
| 89% (93/104) | 91% (102/112) | 100% (104/104) | 88% (99/112) | 83% (86/104) | 87% (97/112) | 86% (89/104) | 84% (94/112) |
| Cumulative evaluation on validation + test sets | Cumulative evaluation on validation + test sets |
Cumulative evaluation on validation + test sets |
Cumulative evaluation on validation + test sets |
||||
| 90% (195/216) | 94% (203/216) | 85% (183/216) | 85% (183/216) | ||||