Table 7. Summary table of Phase-1 prediction results over all test data belonging to non-single cluster lengths, for CDR-L1 and -L3.
Percentages are rounded to the closest unit. Totals for canonical templates in CDR-L3 are marked in italics because they don’t include predictions for a length of 11-residues (no template available). For a direct comparison, total accurate predictions for DCP signatures for 8-, 9- and 10-resides CDR-L3 were 133/153 (87%). Totals include novel conformations.
| DCP signatures | Canonical templates | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| CDR/Length | Accurately predicted conformations |
Uncertain predictions |
False predictions |
Novel
conformations |
Accurately predicted conformations |
Uncertain predictions |
False predictions |
New CDR sequences in test set (not present in training set) |
Unique CDR sequences in training set |
| CDR-L1-11 | 97/107 (91%) | 0/105 | 0/107 | 10/107 (9%) | 93/107 (87%) | 4/107 (4%) | 0/107 | 68/107 (64%) | 177 |
| CDR-L1-12 | 11/14 (79%) | 0/14 | 2/14 (14%) | 1/14 (7%) | 8/14 (57%) | 4/14 (29%) | 1/14 (7%) | 11/14 (79%) | 25 |
| CDR-L1-13 | 16/17 (94%) | 0/17 | 0/17 | 1/17 (6%) | 16/17 (94%) | 0/17 | 0/17 | 15/17 (88%) | 26 |
| CDR-L1-14 | 10/10 (100%) | 0/10 | 0/10 | 0/10 | 10/10 (100%) | 0/10 | 0/10 | 6/10 (60%) | 26 |
| CDR-L1-15 | 11/11 (100%) | 0/11 | 0/11 | 0/11 | 10/11 (91%) | 1/11 (9%) | 0/11 | 9/11 (82%) | 16 |
| CDR-L1-16 | 18/18 (100%) | 0/18 | 0/18 | 0/18 | 18/18 (100%) | 0/18 | 0/18 | 10/18 (56%) | 71 |
| Total | 163/177 (92%) | 0/177 | 2/177 (1%) | 12/177 (7%) | 155/177 (88%) | 9/177 (5%) | 1/177 (0.5%) | 119/177 (67%) | 341 |
| CDR-L3-8 | 18/19 (95%) | 0/19 | 1/19 (5%) | 0/19 | 17/19 (89%) | 1/19 (5%) | 1/19 (5%) | 12/19 (63%) | 44 |
| CDR-L3-9 | 111/119 (93%) | 1/119 (1%) | 6/119 (5%) | 1/119 (1%) | 110/119 (92%) | 4/119 (3%) | 4/119 (3%) | 84/119 (71%) | 359 |
| CDR-L3-10 | 4/15 (27%) | 0/15 | 4/15 (27%) | 7/15 (47%) | 4/15 (27%) | 2/15 (13%) | 2/15 (13%) | 14/15 (93%) | 26 |
| CDR-L3-11 | 19/25 (76%) | 0/25 | 1/25 (4%) | 5/25 (20%) | N/A | N/A | N/A | 23/25 (92%) | 36 |
| Total | 152/178 (85%) | 1/178 (1%) | 12/178 (7%) | 13/178 (7%) | 131/153 (86%) | 7/153 (5%) | 7/153 (5%) | 133/178 (75%) | 465 |