(A) Hierarchical clustering of the 16 investigated tissues and the
identified acetylated proteins based on label-free quantification on their
summed MS peptide signal intensities. Low-intensity proteins are depicted in
blue, and high-intensity proteins are depicted in yellow. Protein clusters of
highly abundant acetylated proteins are highlighted by red boxes. The table
summarizes the number of lysine-acetylated proteins and sites identified in each
tissue as well as the average number of acetylation sites per protein.
(B) Pathway enrichment analysis for all identified acetylated proteins
as well as for acetylated proteins enriched in the main tissue clusters compared
to all other tissues. Logarithmized corrected p values for significant
overrepresentation are shown. In parenthesis we indicate how many proteins in
each pathway we identify to be acetylated.
See also Figure S3.