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. Author manuscript; available in PMC: 2014 Jul 18.
Published in final edited form as: Cell Metab. 2010 Nov 3;12(5):509–520. doi: 10.1016/j.cmet.2010.10.005

Fig 6. Distinct pathways regulated by PER2.

Fig 6

(A) Classical view of PER2 association with CRY to repress CLOCK:BMAL1-directed transcription to control circadian rhythms. (B) Here we have shown that PER2 functions as a critical metabolic regulator by repressing, in a CRY-independent manner, PPARγ-mediated activation of genes involved in adipogenesis and lipid metabolism. (C) We envisage that PER2 may contribute to the regulation of other pathways by specific interactions with selected, tissue-specific transcription factors.