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. Author manuscript; available in PMC: 2015 Jan 1.

Published in final edited form as: J Cardiovasc Pharmacol Ther. 2013 Nov 28;19(1):121–132. doi: 10.1177/1074248413508003

Lack of influence of Bendavia on permeability transition pore (PTP) opening in isolated mitochondria subjected to a calcium pulse. A. Mitochondria were energized with glutamate/malate. The positive controls MPG (a radical scavenger), MnTBAP (a manganese superoxide dismutase mimetic), and CsA (cyclosporin-A, a direct PTP blocker) were utilized for comparison with Bendavia. B. Experiments were repeated under de-energized conditions (no glutamate/malate). PTP opening is depicted by mitochondrial swelling, which is reflected by a decrease in the absorbance of light at 520nm. *, P<0.05 (ANOVA).

Lack of influence of Bendavia on permeability transition pore (PTP) opening in isolated mitochondria subjected to a calcium pulse. A. Mitochondria were energized with glutamate/malate. The positive controls MPG (a radical scavenger), MnTBAP (a manganese superoxide dismutase mimetic), and CsA (cyclosporin-A, a direct PTP blocker) were utilized for comparison with Bendavia. B. Experiments were repeated under de-energized conditions (no glutamate/malate). PTP opening is depicted by mitochondrial swelling, which is reflected by a decrease in the absorbance of light at 520nm. *, P<0.05 (ANOVA).