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ASPP2 is up-regulated in mouse models and human neuroinflammatory disorders. ASPP2 induction in (A) an animal model of multiple sclerosis and (B) human encephalitis. (C) ASPP2 is up-regulated in GFAP-positive reactive astrocytes. STAT1 (red) and ASPP2 (green) coexpression in GFAP-positive reactive astrocytes (white). (Scale bars: 25 µm.) (D) Proposed mechanism of ASPP2/STAT1-induced apoptosis in response to inflammatory stimuli.
