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Diverse macrolides induce ribosome stalling with the MRL nascent peptide. Toeprinting analysis of ribosomes stalled during translation of the s-ermDL ORF induced by macrolide ERY, ketolide SOL, or azalide AZI. Drug-induced toeprint representing arrest at the Leu codon (black box) is indicated by a black arrowhead. Gray arrowheads and box indicate macrolide-independent translation arrest at the Pro codon due to the presence of mupirocin, which depletes Ile–tRNA in the reaction.
