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. 2014 Jul 18;5:374. doi: 10.3389/fmicb.2014.00374

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Copyright © 2014 Wesolowska, Richter-Dennerlein, Lightowlers and Chrzanowska-Lightowlers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of a composite ribosome to show relative positions occupied by ICT1 and YaeJ. Truncated mRNA lacking an A-site codon allows ingress of YaeJ such that the C-terminal α-helix aligns within the mRNA entry channel in the small subunit (SSU). This positions the GGQ motif at the peptidyl transferase centre (PTC) allowing cleavage of the ester bond between the P-site tRNA and the truncated polypeptide (as described in Kogure et al., 2014). The aborted product is then released via the polypeptide exit site in the large subunit (LSU). ICT1 by contrast is located at the central protuberance (CP) precluding its interaction with the nascent peptide without a large scale conformational change of the ribosome (as described in Greber et al., 2013).