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FAN1Domain Schematic and Catalytic Activity
(A) Domain organization of hFAN1 and pFAN1. hFAN1 domain boundaries from Smogorzewska et al. (2010).
(B) Endonucleolytic cleavage of 5′-labeled 5′ flap DNA by human FAN1 and orthologs.
(C) 5′-3′ exonucleolytic cleavage of 3′-labeled 5′ flap DNA by human FAN1 and orthologs.
(D) Progression of a- and b-strand 5′ flap cleavage by pFAN1.
(E) Schematic of the proposed mechanism of pFAN1 activity on 5′ flaps.
