Table 1.

Dosage Adjustment for Ibrutinib Toxicities¹⁰

Dose modification for nonhematological and hematological toxicities should take place upon improvement to grade 1 toxicity or return to baseline (recovery).
First occurrence	Restart at 420 mg/day
Second occurrence	Restart at 280 mg/day
Third occurrence	Restart at 140 mg/day
Fourth occurrence	Discontinue ibrutinib