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. Author manuscript; available in PMC: 2014 Jul 18.
Published in final edited form as: FEMS Microbiol Rev. 2013 Oct 31;38(3):473–492. doi: 10.1111/1574-6976.12046

Figure 4. The Fsr QS system of E. faecalis.

Figure 4

FsrD, the gelatinase biosynthesis activating pheromone (GBAP) precursor, is processed to a cyclical peptide during secretion by FsrB. Mature GBAP pheromone interacts with the FsrC sensor kinase on the surface of surrounding cells causing phosphorylation of the DNA-binding response regulator, FsrA. Phosphorylated FsrA binds to promoters, including those of fsrB and gelE/sprE, and upregulates gene expression.