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Reep6 knockdown caused photoreceptor cell death in adult mouse retina. Representative confocal images of P21 mouse retina. Retina of CD1 mice were transfected at P0 with Ub-GFP (electroporation control), Gapdh shRNA (control shRNA) or Reep6 shRNA. The transfection was tracked by GFP (green). Rods are highlighted by rhodopsin immunoreactivity (red), and nuclei were visualized by DAPI (blue). Scale bar = 10 μm.
