Table 3.

Sex-specific effect of rs1212665 and rs2071403 on TSH concentration and anti-TPO antibody positivity

					Male				Female
Variant	Chr	Position (bp)	A1	Nearby gene	N	β/OR	SE	P	N	β/OR	SE	P
rs12126655	1	108 158 343	G	VAV3	1535	0.108	0.036	2.7 × 10−3	1964	0.157	0.034	2.7 × 10−6
rs2071403	2	1 396 251	A	TPO	1881	0.749	0.135	3.2 × 10−2	2337	0.551	0.095	4.1 × 10−10
	Joint male and female
	N	β/OR	SE	P	I2	Het P
rs12126655	3499	0.134	0.025	6.1 × 10−8	0	0.322
rs2071403	4218	0.610	0.078	2.3 × 10−10	71	0.063

Associations were tested with minor alleles by linear regression for TSH concentration and by logistic regression for anti-TPO antibody positivity. For TSH concentration, the effect size is shown as β and for anti-TPO antibody positivity as odds ratio (OR). The minor allele and its physical position are indexed to the positive strand of the NCBI build 36. The nearby gene is defined as the gene nearest to the variant within the boundary of the 50-kb distance. Chr, chromosome number; A1, minor allele; N, number of subjects; MAF, minor allele frequency; β, effect size of linear regression; SE, standard error; I², heterogeneity estimate; Het P, P-value for heterogeneity.