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. 2014 Jul 18;9(7):e99284. doi: 10.1371/journal.pone.0099284

Figure 5. Behavioral, hemodynamic and respiratory responses to oxytocin antagonist.

Figure 5

(A) Grooming score average count of the 5-min behavior sampling window of the saline+oxytocin (SAL+OT) 1 µg and vasotocin+OT (OTA+OT) 1 µg groups. (B) Grooming score (mean of 60 min) of the SAL+OT 1 µg (open bar) and OTA+OT 1 µg (black bar) groups. Time-course of (C) mean arterial blood pressure (ΔMABP, mmHg), (E) heart rate (ΔHR, bpm) and (G) minute ventilation (ΔVE, mL.Kg−1.min−1) changes for 60 min after bilateral microinjections of OT 1 µg into the central nucleus of amygdala (CeA) in the SAL+OT 1 µg and OTA+OT 1 µg groups. Maximum responses in (D) mean arterial blood pressure (ΔMABP, mmHg) at 50 min, (F) heart rate (ΔHR, bpm) at 5 min and (H) minute ventilation (ΔVE, mL.Kg−1.min−1) at 5 min after bilateral microinjections of OT 1 µg into the CeA in the SAL+OT 1 µg (open bars) and OTA+OT 1 µg (black bars) groups. The arrow indicates the moment of microinjections. Data shown represent the means ± standard error of mean. (*) SAL+OT 1 µg group vs VASO+OT 1 µg group; p<0.05, Poisson model.