Table 2.

Associations between Statin Use or Discontinuation and Delirium during Study Days 1–5 (Sensitivity Analyses Results)^a,^b

Exposure	Association with Delirium
	Odds Ratio	95% Confidence Interval
Statin Usea
In the ICUb
With sepsisc	0.45	0.22 to 0.94
Without sepsisc	0.92	0.42 to 2.05
Prehospital
All patientsd	0.85	0.44 to 1.66
Statin Discontinuatione
All patientsd	2.24	1.17 to 4.26

Abbreviations: CI, confidence interval.

^aResults show the odds ratio for delirium associated with use of a statin in the ICU or during the prehospital period (with no statin exposure being the reference comparator), after adjusting for age, baseline cognitive function, Framingham Stroke Risk profile, propensity score for prehospital statin use, severity of illness, sepsis, mechanical ventilation, sedative and analgesic doses, steroid use, and study day.

^bDuring study days 1–5, the association between ICU statin use and delirium was not significantly modified by study day (interaction p for study day*ICU statin use = 0.96), all interaction terms were retained in the model because of the significant interaction between sepsis and ICU statin use (see footnote c). Thus, the odds ratios (and corresponding confidence intervals) displayed are specific to study day 3 (the median study day in this sensitivity analysis) but do not significantly different from the results specific to other study days.

^cDuring study days 1–5, the association between ICU statin use and delirium was significantly modified by sepsis (interaction p for sepsis*ICU statin use = 0.02); the odds ratios (and corresponding confidence intervals) are therefore shown according to whether sepsis was present or absent. Sepsis status was determined on a daily basis (i.e., patients could be septic on one day and non-septic on the next) according to international consensus criteria (40).

^dDuring study days 1–5, neither the association between prehospital statin use and delirium nor between statin discontinuation and delirium were modified by sepsis (interaction p = 0.46 and 0.22, respectively); the odds ratios (and corresponding confidence intervals) are therefore shown for all patients rather than according to whether sepsis was present or absent.

^eResults show the odds ratio for delirium associated with 3 days of statin discontinuation (with 0 days being the reference comparator), after adjusting for age, baseline cognitive function, Framingham Stroke Risk profile, severity of illness, sepsis, mechanical ventilation, sedative and analgesic doses, steroid use, and study day.