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. Author manuscript; available in PMC: 2015 Jul 16.
Published in final edited form as: Neuron. 2014 Jun 26;83(2):444–454. doi: 10.1016/j.neuron.2014.05.028

Figure 1. Differential regulation of Tac2 gene expression in the amygdala during cued-fear conditioning.

Figure 1

A) With average linkage hierarchical clustering of a RNA microarray there is a differential gene regulation 30 minutes and 2 hours after auditory fear conditioning (FC) when compared to home cage group (no FC). N=4 per group. B) Tac2 mRNA levels are rapidly up-regulated in the amygdala during fear consolidation 30 minutes after fear conditioning. *P ≤0.05 vs HC and 2 hrs. N=7-8 per group. C) Tac2 up-regulation occurs when the conditioned stimulus (acoustic tone) and the unconditioned stimulus (electric footshock) are paired but not when they are unpaired. *P ≤0.05 vs HC and unpaired. N=11-15 per group. Mean + SEM is shown. D) Tac2 expression by radioactive in situ hybridization in the amygdala is restricted to the central amygdala (CeA) with highest expression in the CeM amygdala. Scale bar = 1 mm. See also Figure S1 and Table S1 and S2.