Table 4.
MIC distribution in methicillin-resistant S. aureus isolates from bovines
|
Antimicrobials |
% of isolates with MIC (mg/l) of |
% R |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.016 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | 256 | 512 | ||
| CHL |
|
|
|
|
|
|
|
|
4.9 |
46.9 |
35.8 |
2.5 |
8.6 |
1.2 |
|
|
12.3 |
| CIP |
|
|
|
|
18.5 |
27.2 |
9.9 |
2.5 |
2.5 |
11.1 |
28.4 |
|
|
|
|
|
16.0 |
| CLI |
|
|
|
12.3 |
1.2 |
1.2 |
1.2 |
0.0 |
0.0 |
84.0 |
|
|
|
|
|
|
86.4 |
| ERY |
|
|
|
|
3.7 |
7.4 |
2.5 |
0.0 |
2.5 |
2.5 |
81.5 |
|
|
|
|
|
86.4 |
| FOX |
|
|
|
|
|
0.0 |
0.0 |
0.0 |
0.0 |
3.7 |
18.5 |
77.8 |
|
|
|
|
100.0 |
| FUS |
|
|
|
|
|
72.8 |
12.3 |
2.5 |
9.9 |
2.5 |
|
|
|
|
|
|
27.2 |
| GEN |
|
|
|
|
|
|
22.2 |
1.2 |
3.7 |
7.4 |
21.0 |
44.4 |
|
|
|
|
76.5 |
| KAN |
|
|
|
|
|
|
|
|
16.0 |
3.7 |
2.5 |
2.5 |
9.9 |
65.4 |
|
|
80.2 |
| LZD |
|
|
|
|
|
|
23.5 |
75.3 |
1.2 |
0.0 |
|
|
|
|
|
|
0.0 |
| MUP |
|
|
|
|
|
86.4 |
3.7 |
3.7 |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
6.2 |
|
9.9 |
| PEN |
|
|
|
0.0 |
0.0 |
0.0 |
1.2 |
8.6 |
90.1 |
|
|
|
|
|
|
|
100.0 |
| RIF |
86.4 |
1.2 |
0.0 |
1.2 |
0.0 |
1.2 |
9.9 |
|
|
|
|
|
|
|
|
|
12.3 |
| SMX |
|
|
|
|
|
|
|
|
|
|
|
|
70.4 |
3.7 |
11.1 |
14.8 |
25.9 |
| STR |
|
|
|
|
|
|
|
|
14.8 |
22.2 |
4.9 |
9.9 |
48.1 |
|
|
|
58.0 |
| SYN |
|
|
|
|
|
32.1 |
44.4 |
8.6 |
8.6 |
6.2 |
|
|
|
|
|
|
23.5 |
| TET |
|
|
|
|
|
2.5 |
1.2 |
0.0 |
0.0 |
0.0 |
1.2 |
95.1 |
|
|
|
|
96.3 |
| TIA |
|
|
|
|
|
75.3 |
7.4 |
0.0 |
0.0 |
17.3 |
|
|
|
|
|
|
17.3 |
| TMP |
|
|
|
|
|
|
|
4.9 |
3.7 |
1.2 |
0.0 |
1.2 |
88.9 |
|
|
|
95.1 |
| VAN | 87.7 | 12.3 | 0.0 | 0.0 | 0.0 | 0.0 | |||||||||||
CHL, chloramphenicol; CIP, ciprofloxacin; CLI, clindamycin; ERY, erythromycin; FOX, cefoxitin FUS, fusidic acid; GEN, gentamicin; KAN, kanamycin; LZD, linezolid; MIC, minimal inhibitory concentration; MUP, mupirocin; PEN, penicillin; R, resistance; RIF, rifampicin; SMX, sulfamethoxazole; STR, streptomycin; SYN, quinupristin/dalfopristin; TET, tetracyclin; TIA, tiamulin; TMP, trimethoprim; VAN,vancomycin.
Empty boxes indicate the concentration values that were not tested. Values in grey boxes indicate MIC higher than the concentration tested.
The bold lines indicate epidemiological cut-off values for S. aureus. MIC values were interpreted using the EUCAST clinical breakpoints/epidemiological cut-offs [1].