Table 1.
Group | Microscopic observation | ||||||
---|---|---|---|---|---|---|---|
Histological activity index a | Necrosis or apoptosis | Hemorrhage | Disorganized sinusoids | Infiltration of lymphocytes | Hyperplasia of Kupffer cells | Hepatocytic swelling | |
Control | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
PZQ | 3 | 0 | 0 | + | + | 0 | 0 |
BER | 2 | + | 0 | 0 | + | 0 | 0 |
Infected | 14-16 | +++ | +++ | ++ | +++ | +++ | ++ |
Infected + PZQ | 9-11 | ++ | + | + | ++ | ++ | + |
Infected + BER | 9-12 | + | + | + | ++ | + | + |
aModified according to Ishak et al. [17]. Score: 1–3, minimal; 4–8, mild; 9–12, moderate; 13–18, severe. 0: absent; +: mild; ++; moderate; and +++: severe.