Fig. 1.

Alignment of human HCaRG/COMMD5 and COMMD1 proteins, excluding the COMM domain. While COMM domains of the COMMD protein family are highly conserved, HCaRG has only 13 % homology with COMMD1. Asterisks indicate positions with a single, fully-conserved residue. Colons depict strongly similar properties—scoring >0.5 in the Gonnet PAM 250 matrix. Periods indicate weak similarity—scoring ≤0.5 in the Gonnet PAM 250 matrix. HCaRG hypertension-related calcium-regulated gene, COMM copper metabolism MURR1