Figure 1.

Clearance of corticosterone in Srd5a1-KO and WT mice. Plasma corticosterone concentrations following (A) corticosterone bolus injection and (B) chronic infusion were higher in adrenalectomised mice deficient in 5α-reductase 1 (KO, open circles/white bars) than in WT mice (WT, black squares/bars). Amounts of corticosterone in (C) liver and (D) brain were higher in KO than in WT mice following chronic infusion of corticosterone. *P<0.05 versus WT.