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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Adv Virus Res. 2014;88:111–159. doi: 10.1016/B978-0-12-800098-4.00002-7

Table 1.

Characteristics of KSHV-associated malignancies

Disease Presentation Lineage &
Primary Tumor
Cell		 Clonality KSHV
Genomes
Kaposi’s sarcoma (KS) Highly angiogenic. Lesions can be found on skin, visceral organs, or mucosal surfaces Endothelial cell origin; tumor cells are spindle cells with mixed blood and lymphatic endothelial cell markers Oligoclonal lesions >99% of tumor cells contain KSHV genomes
Primary Effusion Lymphoma (PEL) Non-Hodgkin lymphoma; B cell expansion in body cavity B cell; CD20-; markers resemble partially differentiated plasma cell Monoclonal Each tumor cell has 50–100 copies of the KSHV genome
MulticentricCastleman’s Disease (MCD) Plasmablastic variant of MCD B cell; IgM λ-restricted plasmablasts Typically polyclonal Unknown