Figure 1.

(a) Treatment strategy of LNCaP xenograft tumor in nude mice. After the tumor establishment, animals were castrated and tumors are allowed to regress for 10–14 days, which was considered as the ‘on-cycle’ of androgen ablation during intermittent androgen deprivation (IADT). The animals were then implanted with no pellet, testosterone (T) pellet, finasteride (F) pellet or both T and F pellets for 14 days or longer. Testosterone implantation mimics intermittent recovery of testicular function during the ‘off-cycle’ of IADT. Controls were continuous androgen deprivation (ADT) in the absence or presence of finasteride. (b) Kaplan-Meier survival curve of indicated treatment groups. Euthanasia was performed if tumor diameter > 2.0 cm, tumor ulceration or tumor-related morbidity. *P < 0.05. From Eggener et al.55