Risk of incident major adverse cardiovascular events (MACE), as derived from Kaplan–Meier curves (a), according to waist circumference (WC) classes. (b) Age, lifestyle (smoking and alcohol habits) and associated morbidity-adjusted risk for MACE, according to WC thresholds, as derived from Cox regression analysis in the whole sample. (c) Age, lifestyle (smoking and alcohol habits) and associated morbidity-adjusted risk for MACE, according to each centimeter increment in WC as derived from Cox regression analysis in the whole population or according to the median age of the cohort (55 years). Data are derived from a consecutive nonselected series of 1687 patients attending our unit, with a mean follow-up of 4.3 ± 2.6 years.84,85,86,87,88