. Author manuscript; available in PMC: 2015 Jul 1.

Published in final edited form as: J Am Acad Child Adolesc Psychiatry. 2014 May 10;53(7):726–735. doi: 10.1016/j.jaac.2014.04.014

Table 3.

Results of the Linear Mixed Models: Effect of Cognitive Behavioral Versus Supportive Therapy Over Time for Depression Severity, Psychosocial Functioning, Quality of Life and Disease Activity in Youth With Inflammatory Bowel Disease (IBD) and Depression

Outcome	N	Treatment effect coefficient (β)	95% CI	Test Statistic (p-value)
Primary Outcome
Depression severity CDRS-R	217	2.55	0.96, 6.06	z =1.42 (.16)
Secondary Outcomes
Psychosocial functioning CGAS	217	−1.46	−2.96, 0.04	z = −1.90 (.06)
IBD Quality of Life IMPACT-III^a	184	−6.42	−13.28, 0.45	z = −1.83 (.07)
IBD Activity PCDAI/PUCAI (Pooled activity Z scores	210	0.31	0.008, 0.62	z = 2.01 (.04)^b

Note: CBT = cognitive behavioral therapy; CDRS-R = Children’s Depression Rating Scale-Revised; CGAS = Children’s Global Assessment Scale; PCDAI = Pediatric Crohn’s Disease Activity Index; PUCAI = Pediatric Ulcerative Colitis Activity Index; SNDT = supportive non-directive therapy.

IMPACT-III is a health-related quality of life assessment.

Indicates statistical significance CBT>SNDT