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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Pain. 2014 May 17;155(8):1632–1648. doi: 10.1016/j.pain.2014.05.015

Figure 5. Brain mediators of the relationship between stimulus and response.

Figure 5

A) Mediators of the relationship between temperature and pain. Brain regions whose responses to noxious stimulation formally mediate the relationship between temperature and pain include those that were activated consistently across the group, as well as those that show covariance between paths. B) Consistent mediators (significant Path a and Path b effects across subjects). Regions that were activated consistently across the group include both regions that showed temperature- and pain-related increases, illustrated in red, as well as those that showed temperature- and pain-related decreases, illustrated in blue.