Fig. 1.

The 12Gso chromosome translocation is an allele of Tbx18 and produces recessive phenotypes that are similar to the Tbx18-null mice. (A–E) H&E stained sections of newborn thoracic vertebrae. Fused and malformed vertebrae are indicated with black arrow. (F–J) Alizarin red and alcian blue stained axial skeletons from newborn mice. Expanded proximal ribs are indicated with red arrows. (K–O) Lateral views of newborn thoracic skeletons. Fused pedicles of adjacent vertebrae are indicated with red arrows. (P–T) Hematoxylin and Eosin stained sections of newborn kidneys and ureters. 12Gso/12Gso and 12Gso/Tbx18⁻ newborns display patent hydroureter (black arrows). (U–Y) Newborn urogenital systems in whole mount. The dilated ureters are outlined in black for clarity.