Table 2.

Dose Escalation and Toxicity (first cycle)

Dose Level	Dose (mg)	No. of Patients	No. of Cycles		No. of Patients With Unacceptable Toxicity in First Cycle
			Total	Median
Bolus IV injection
1	1.2	3	5	1	0
2	2.5*	10	32	2	0
3	4.0	3	4	1	2
1-hour IV infusion
1	2.5*	10	30	1.5	1
2	3.0	6	8	1	2

Abbreviation: IV, intravenous.

^*Maximum-tolerated dose.