Table 3.
No. of Occurrences of Most Common Drug-Related Toxicities During EC145 Therapy*
| Toxicity | Bolus IV Injection (grade) |
1-Hour IV Infusion (grade) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1.2 mg (n = 3) |
2.5 mg (n = 10) |
4.0 mg (n = 3) |
2.5 mg (n = 10) |
3.0 mg (n = 6) |
|||||||||||
| 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 | |
| Constipation | 1 | — | — | 1 | 3 | 1 | — | 1 | 1 | 1 | 3 | — | 1 | 1 | 2 |
| Nausea | — | — | — | 2 | 4 | — | 1 | 1 | — | 3 | — | — | 1 | — | — |
| Vomiting | 1 | — | — | 2 | 3 | — | — | 1 | — | 2 | — | — | 2 | — | — |
| Fatigue | 1 | 1 | — | 1 | 2 | 1 | — | 2 | — | 1 | 2 | 1 | — | 3 | — |
| Peripheral sensory neuropathy | 1 | 1 | — | 3 | 1 | — | — | — | — | 2 | — | 1 | 2 | — | — |
Abbreviation: IV, intravenous.
*
Reported in ≥ 10% of patients.