Table 4.
Pharmacokinetic Parameters for EC145
| Parameter | Bolus IV Injection (2.5 mg) |
1-Hour IV Infusion (2.5 mg) |
||||||
|---|---|---|---|---|---|---|---|---|
| Day 1 (n = 10) |
Day 3 (n = 7) |
Day 1 (n = 10) |
Day 3 (n = 10) |
|||||
| Mean | Coefficient of Variation (%) | Mean | Coefficient of Variation (%) | Mean | Coefficient of Variation (%) | Mean | Coefficient of Variation (%) | |
| Cmax, ng/mL | 134.3 | 43.8 | 123.2 | 6.2 | 38.6 | 64.7 | 44.8 | 43.1 |
| Tmax, minutes | 5.5 | 15.5 | 5.1 | 6.2 | 66.0 | 19.6 | 66.0 | 18.6 |
| AUClast, ng × h/mL | 43.0 | 48.3 | 40.2 | 38.0 | 36.0 | 79.0 | 43.2 | 47.2 |
| AUC∞, ng × h/mL | 50.1 | 38.1 | 49.9 | 25.3 | 57.6 | 71.5 | 70.9 | 25.3 |
| t1/2, minutes | 19.9 | 52.9 | 21.5 | 38.6 | 25.3 | 30.6 | 33.6 | 34.3 |
| CL, L/h | 46.9 | 50.2 | 56.8 | 46.0 | 59.7 | 54.6 | 41.6 | 39.7 |
| Vd, L | 21.9 | 38.1 | 26.6 | 32.6 | 32.7 | 41.4 | 32.9 | 60.6 |
| λz, h−1 | 3.0 | 36.5 | 2.3 | 38.6 | 1.8 | 39.6 | 1.5 | 50.8 |
Abbreviations: λz, apparent terminal-phase disposition rate constant (first order); AUC∞, area under the concentration-time curve from zero to infinity; AUClast, AUC from zero to the last observable concentration; Cmax, peak (maximum) plasma concentration; CL, clearance; IV, intravenous; t1/2, half-life; Tmax, time to peak (maximum) plasma concentration; Vd, volume of distribution.