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. Author manuscript; available in PMC: 2014 Jul 21.
Published in final edited form as: Cell. 2009 Jan 9;136(1):97–109. doi: 10.1016/j.cell.2008.11.013

Fig. 7. Speculative model for the ESCRT-III reaction cycle.

Fig. 7

ESCRT-III assembly is initiated when Vps20 binds to Vps25 on the membrane surface. In the second stage, Snf7 binds to the membrane-bound Vps25-Vps20 complex, and this triggers the formation of a membrane-bound Snf7 oligomer. The Snf7 oligomer traps cargo into a localized sorting domain and induces membrane deformation. Vps24 caps the Snf7 oligomer, and interactions between Vps2 and Vps4 initiate membrane disassembly of the ESCRT-III complex (see Discussion).