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Lactate suppresses TLR primed NLRP3 inflammasome activity. Murine peritoneal macrophages were treated with LPS, ATP, and lactate, and then assessed for CASP1 cleavage to the P10 subunit in Western blots (A), caspase 1 activity (B), and IL1b release into the supernatant (C). Human peripheral blood mononuclear cells treated with LPS, ATP, and lactate and assessed for IL1brelease (D). Asterisks denote significant difference (P<0.05) between treatment groups.
