Table 1. Antipsychotic Treatment Response by Genotype as Assessed by the Positive and Negative Syndrome Scale (PANSS).

	NRXN1_rs12467557				NRXN1_rs10490162
	Estimatea	t	p	p*	Estimatea	t	p	p*
Negative syndrome				0.0447				0.0863
AA	−1.45	−2.94	0.0051		−1.57	−2.98	0.0047
AG+GG	1.80	1.19	0.2399		0.54	0.5	0.6219
Positive syndrome				0.0324				0.2319
AA	−1.35	−3.29	0.002		−1.34	−2.99	0.0045
AG+GG	1.55	1.23	0.2265		−0.10	−0.11	0.9139
General psychopathology				0.0029				0.1397
AA	−3.01	−2.96	0.005		−2.94	−2.54	0.0146
AG+GG	7.30	2.32	0.025		1.01	0.43	0.6728
Anergia				0.0223				0.0225
AA	−0.58	−2.01	0.0505		−0.70	−2.29	0.0266
AG+GG	1.60	1.81	0.0772		0.95	1.5	0.1409
Thought disturbance				0.0080				0.1187
AA	−0.95	−3.51	0.001		−0.95	−3.16	0.0029
AG+GG	1.45	1.75	0.0873		0.14	0.23	0.8186
Activation				0.1600				0.4347
AA	−0.73	−2.98	0.0046		−0.73	−2.78	0.008
AG+GG	0.39	0.52	0.6082		−0.26	−0.47	0.6372
Paranoid belligerence				0.0459				0.2725
AA	−0.26	−1.58	0.1212		−0.25	−1.43	0.1598
AG+GG	0.81	1.63	0.1115		0.19	0.53	0.596
Depression				0.1302				0.6567
AA	−0.62	−1.59	0.1183		−0.56	−1.34	0.1869
AG+GG	1.30	1.09	0.2832		−0.14	−0.16	0.8747

p*, p values for interaction between SNPs and treatment on PANSS ratings adjusted for duration of illness.

A=common allele, G=minor allele.

^aEstimates reflects mean difference in PANSS ratings between placebo and treatment arms by genotype based on post-hoc least-square estimation from the general linear mixed model.