Table 3.

Rate of change of maternal plasma angiogenic factors from first to late second trimester (23–26 weeks of gestation)

	Normotensive (n = 375)	Pre- eclampsia (n = 137)	P*	Severe PE (n = 54)	P**	Early-onset PE (n = 15)	P***
sFlt (pg/ml)
First trimester	1290 (840–1820)	1110 (762–1680)	0.038	943 (741–1430)	0.001	949 (625–1450)	0.038
Second trimester (23–26 weeks)	1480 (967–2360)	1570 (924–2570)	0.59	1620 (924–3220)	0.39	1570 (924–4350)	0.52
Rate of change (pg/ml/week)	16.4 (−17.9 to 60.6)	23.1 (−7.8 to 81.0)	0.044	43.0 (7.9–100.1)	<0.001	20.6 (1.6–249.2)	0.09
Endoglin (ng/ml)
First trimester	4.4 (3.7–5.3)	4.4 (3.6–5.5)	0.81	4.3 (3.6–5.2)	0.52	3.7 (3.5–4.8)	0.15
Second trimester (23–26 weeks)	4.2 (3.6–5.2)	4.3 (3.7–5.5)	0.34	4.9 (3.9–6.0)	0.013	4.9 (3.4–7.2)	0.33
Rate of change (ng/ml/week)	−0.007 (−0.09 to 0.05)	−0.004 (−0.08 to 0.06)	0.20	0.032 (−0.03 to 0.09)	0.002	0.02 (−0.02 to 0.18)	0.06
PlGF (pg/ml)
First trimester	27.4 (18.6–38.4)	22.4 (14.8–31.7)	< 0.001	22.0 (15.5–27.6)	< 0.001	26.0 (14.6–45.1)	0.63
Second trimester (23–26 weeks)	360 (252–558)	240 (151–398)	< 0.001	210 (133–366)	< 0.001	169 (85–366)	0.002
Rate of change (pg/ml/week)	25.6 (16.7–40.4)	16.8 (9.5–26.6)	< 0.001	13.8 (8.9–24.5)	< 0.001	9.5 (4.8–25.6)	0.003

PE, pre-eclampsia.

Data presented as median (25–75th centile).

^*Pre-eclampsia compared with normotensive.

^**Severe pre-eclampsia compared with normotensive.

^***Early onset pre-eclampsia compared with normotensive.