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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: BJOG. 2013 Jan 18;120(10):1183–1191. doi: 10.1111/1471-0528.12128

Table 5.

Area under the curve from receiver operating curves and sensitivity at a fixed 80% specificity for changes in biomarker concentrations adjusted for race, BMI and blood pressure between first and late second trimesters with severe or early-onset pre-eclampsia

Biomarker
(rate of
change)		 Pre-eclampsia (n = 137) Severe pre-eclampsia
(n = 54)		 Early-onset pre-eclampsia
(n = 15)
AUC
(95% CI)		 Sensitivity
(95% CI)		 AUC
(95% CI)		 Sensitivity
(95% CI)		 AUC
(95% CI)		 Sensitivity
(95% CI)
sFlt 0.71 (0.66–0.76) 47.4 (38.9–56.1) 0.73 (0.65–0.80) 57.4 (43.2–70.8) 0.88 (0.81–0.95) 80.0 (51.9–95.7)
Endoglin 0.71 (0.66–0.76) 51.1 (42.4–59.7) 0.72 (0.65–0.80) 46.3 (32.6–60.4) 0.87 (0.81–0.94) 73.3 (44.9–92.2)
PlGF 0.70 (0.65–0.76) 48.2 (39.6–56.9) 0.73 (0.65–0.81) 59.3 (45.0–72.4) 0.85 (0.76–0.93) 73.3 (44.9–92.2)