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. Author manuscript; available in PMC: 2014 Dec 20.
Published in final edited form as: Stat Med. 2013 Jul 16;32(29):5039–5052. doi: 10.1002/sim.5902

Figure 1.

Figure 1

The figure displays conceptually the interplay of genetic and pathologic tumor characteristics (denoted by {yi}) and risk profiles (denoted by {xi}) that are used interactively to determine the set of subtypes that best characterize etiologic heterogeneity.