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Porcine aortic cusp mounted on biaxial micromechanical testing device (top panel) and changes in the stiffness of the tissue induced by 5-HT, endothelial denudation, nitric oxide synthase inhibitor (L-NAME), endothelin-1, and cytochalasin B (CyB), an actin depolymerizing agent (bottom panel) (from El-Hamamsy et al., 2009). 123
