Table 1.

Key inclusion and exclusion criteria of the SYMPLICITY HTN-3 trial.

Inclusion Criteria	Exclusion Criteria
Office SBP ≥ 160 mmHg on two clinic visits two weeks apart	Ineligible renal artery anatomy (main renal artery < 4 mm or with < 20 mm treatable length; multiple renal arteries; renal artery stenosis (>50%), previous renal artery intervention)
On stable maximally tolerated doses of 3 or more antihypertensive medications including a diuretic	eGFR < 45 ml/min/1.73 m2
	24hr ABPM SBP < 135 mmHg
	Symptomatic postural hypotension
	Other conditions (including primary  pulmonary hypertension, type 1 diabetes, severe valve stenosis,  acute coronary syndrome or stroke in last 6 months)

SBP – systolic blood pressure; eGFR – estimated glomerular filtration rate; ABPM – ambulatory blood pressure monitor.