Figure 5. Simulation histograms based on cell fate as determined by the fraction of exported Whi5 at the time of pheromone addition.

The cell fate is distinguished by the impulse of Cln1/2. (A) The result of the ODE model with extrinsic noise in the biochemical reaction parameters (σ_brc = 1). (B) The result of the ODE model with extrinsic noise in the biochemical reaction parameters and the mating pathway signal (σ_brc = 1 and σ_mating = 1). (C) The result of the ODE model with extrinsic noise in the biochemical reaction parameters and signal of the cell-cycle pathway (σ_brc = 1 and σ_cycle = 1). (D) The result of the ODE model with extrinsic noise in the biochemical reaction parameters, the signal of the mating pathway and the signal of the cell-cycle pathway (σ_brc = 1, σ_mating = 1 and σ_cycle = 1). R_ex = 1 indicates that the correlation coefficient of the considered types of extrinsic noise equals 1.