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. 2014 Jun 13;11:111. doi: 10.1186/1743-422X-11-111

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Copyright © 2014 Carter et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Anti-DENV group I intron targeting and trans-splicing DENV targets. Illustration of the anti-DENV group I intron, αDENV-U143, targeting the DENV genome and the associated trans-splicing reaction. The targeted 5’ CS domain of the DENV genome is conserved among all serotypes [18]. The uracil at position 143, located within the 5’ CS domain, is targeted for cleavage. Ribozyme and target DENV genomic (blue) RNAs are indicated. IGS = Internal guide sequence, EGS = external guide sequence, CS = cyclization sequence.