Skip to main content
. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: Dev Biol. 2014 Mar 31;390(2):116–125. doi: 10.1016/j.ydbio.2014.03.018

Figure 6. A proposed model for the regulation and functional role of nr2f2 in the early zebrafish trunk vasculature.

Figure 6

The function of nr2f2 is required for some, but not all, venous gene expression in the posterior cardinal vein (PCV), most likely as a positive-acting or permissive factor. Nr2f2 expression itself is positively regulated by the combined activity of sox7 and sox18, each of which are expressed in both the venous and arterial vasculature. Although Notch does not appear to be regulated downstream from nr2f2 during early zebrafish vascular development, Notch signaling activity suppresses expression of nr2f2 in the dorsal aorta, either directly or indirectly, resulting in restriction of nr2f2 expression to the posterior cardinal vein.