Figure 1.
Systems analysis to study the host response to emerging mosquito-borne viruses. (a) Schematic representing the host immune response to virus infection. (b) Traditional scientific methodologies to study the immune response to virus infection have predominantly involved knockout mouse, cell culture, ex vivo infection analysis and the use of a reverse genetics systems to manipulate viruses. Integrating this approach with systems biology and high-throughput based assays can provide a platform to accelerate identification of host targets of therapeutic intervention and improve on current strategies for vaccine design.