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. Author manuscript; available in PMC: 2015 Jun 5.
Published in final edited form as: Mol Cell. 2014 May 22;54(5):820–831. doi: 10.1016/j.molcel.2014.04.026

Figure 4. Targeting OGT Selectively Induces ER Stress-mediated Apoptosis in Cancer Cells.

Figure 4

(A) Cell lysates were collected from MCF-10A and MDA-MB-231 cells after 7 days of lentiviral infection with control, OGT-1, or OGT-2 shRNA. Cells were lysed and expression of proteins were analyzed by immunobloting. (B) Cells expressing control, OGT-1 or OGT-2 shRNA were stained with Annexin V/PI and analyzed by flow cytometry. (C) Cell lysates were collected from cells expressing either control or CHOP shRNA after lentiviral infection with control or OGT-2 shRNA. Cells were lysed and proteins were analyzed by immunobloting. (D) Cells as in (C) were collected, stained with Annexin V/PI and analyzed by flow cytometry. * p-value<0.05. See also Figure S2, S5, S6.