Table 1. Biodistribution of [⁶⁴Cu]RAD1–24.

Pyridine [⁶⁴Cu]RAD1–24 ex vivo biodistribution studies in NOD/SCID mice bearing subcutaneous U87 and U87-stb-CXCR4 brain tumor xenografts; n=3–4 for each time point; reported as percent injected dose per gram tissue (%ID/g).

	Time (minutes)

Organ/Tissue	30	60	90	120	240	480
Blood	3.90 ± 0.57	2.38 ± 0.20	1.71 ± 0.17	1.51 ± 0.24	1.64 ± 0.28	1.82 ± 0.26
Heart	2.46 ± 0.52	2.12 ± 0.18	1.67 ± 0.25	1.56 ± 0.28	1.97 ± 0.09	1.87 ± 0.22
Lungs	14.68 ± 3.21	10.62 ± 1.72	8.43 ± 1.06	6.57 ± 2.50	8.09 ± 1.59	6.10 ± 1.29
Liver	79.45 ± 20.93	91.54 ± 6.03	84.72 ± 9.78	92.83 ± 20.46	101.04 ± 8.94	81.98 ± 11.66
Stomach	2.38 ± 0.51	2.13 ± 0.31	1.86 ± 0.21	1.92 ± 0.44	2.32 ± 0.35	1.91 ± 0.23
Spleen	21.15 ± 5.34	18.61 ± 1.23	16.45 ± 2.76	14.87 ± 2.40	15.20 ± 1.80	12.15 ± 1.95
Kidney	34.00 ± 5.69	39.71 ± 4.03	36.00 ± 3.46	33.44 ± 3.03	35.40 ± 4.75	24.76 ± 1.12
Small Intestines	6.70 ± 2.72	4.97 ± 0.96	4.63 ± 1.16	3.69 ± 1.10	4.73 ± 1.19	3.62 ± 0.63
Muscle	0.46 ± 0.08	0.36 ± 0.05	0.35 ± 0.05	0.36 ± 0.07	0.34 ± 0.02	0.27 ± 0.05
Bladder	2.55 ± 0.58	4.40 ± 2.86	4.14 ± 4.78	1.81 ± 0.57	2.27 ± 0.23	1.22 ± 0.41
Pancreas	1.31 ± 0.18	1.38 ± 0.16	1.27 ± 0.28	1.49 ± 0.05	1.70 ± 0.20	1.30 ± 0.11
U87	5.89 ± 7.01	2.54 ± 0.47	1.98 ± 0.49	2.13 ± 0.72	2.72 ± 0.85	2.92 ± 0.77
U87-stb-CXCR4	13.26 ± 9.83^*	18.95 ± 4.88^*	18.61 ± 2.29^*	18.17 ± 2.03^*	19.60 ± 5.55^*	14.13 ± 7.98^*

P<0.0001 compared to U87 control tumor uptake.

Table 1. Biodistribution of [64Cu]RAD1–24.

Table 1. Biodistribution of [⁶⁴Cu]RAD1–24.