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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Br J Haematol. 2014 Apr 2;166(2):177–188. doi: 10.1111/bjh.12867

Figure 6. Schematic diagram depicting how ibrutinib may affect BCR and CXCR4 signalling in HCL.

Figure 6

Upon antigen stimulation, BCR signalling induces LYN and SYK phosphorylation (P in orange circles refer to phosphorylation) that initiate a signalling cascade causing downstream BTK activation. BTK is recruited into the signalling complex at the plasma membrane via the docking of its pleckstrin homology domain to phosphatidylinositol 3,4,5 triphosphate (PIP3). BTK becomes phosphorylated and therefore induces calcium release, which initiates a signalling cascade with the consequent induction of cell proliferation and survival. BTK is also involved in signalling of chemokine receptor CXCR4, which is important in cell migration and could be a suitable target for ibrutinib.